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The_Skye
Posted: Wednesday, April 11, 2012 8:59:49 AM

Rank: Active Ink Slinger

Joined: 4/9/2012
Posts: 21
Location: United Kingdom
A friend of mine (How cliche) Is pretty skint and has been offered £1800 for a week stay at a residential home testing a Drug.
She's pretty set on it now, and I'm not against it but am concerned.

Generally what are everyones opinion on this?

And has anyone ever been on a clinical trial?

Thanks :) x
Dancing_Doll
Posted: Wednesday, April 11, 2012 9:38:35 AM

Rank: Alpha Blonde

Joined: 2/17/2010
Posts: 6,302
Location: West Coast
No, I haven't tried it and I probably wouldn't.

That's a lot of cash being offered for being a human guinea pig btw - she should really do her research before she signs that waiver. That doesn't mean just relying on what the drug company is telling you about how "safe" it is either. The more sketchy the drug, the more compensation they will offer for clinical trials.

If the drug is FDA approved already though, they are just doing clinical trials to compile more data, then I would be more open to it, especially if I had an existing condition and was paying out-of-pocket for medication. In these cases, patients have the opportunity to try new cutting-edge drugs for free, while being part of a clinical trial - and if they can't afford quality treatment, it's not a bad deal. There's a rigorous process for approval these days, so if it's already approved, you can be more confident in the safety and efficacy.

If the drug is still pending approval - do your research and know what you're getting into with regards to side-effect and long-term complications. See if there is another drug on the market in this same class of drugs and look up how it's fared. Many drugs in the same class will behave similarly to each other.


Nikki703
Posted: Wednesday, April 11, 2012 10:14:05 AM

Rank: Forum Guru

Joined: 8/7/2009
Posts: 12,684
Location: The Other Side Of The Mirror
Based on what they are paying for 1 week trial, I seriously doubt it has FDA approval. She also may not get any benefits from the drug (assuming there are any) as these trials usually have control groups that use placebos and not the actual drug and the participants are not told which group they are in.

Personally, I would never do this unless I had something that was life threatening and it was a last resort. But if she is dead set on it, make sure she finds out all she can about the drug,any potential hazzards and also about the compnay the their past trials.
Dancing_Doll
Posted: Wednesday, April 11, 2012 11:40:55 AM

Rank: Alpha Blonde

Joined: 2/17/2010
Posts: 6,302
Location: West Coast
Nikki703 wrote:
Based on what they are paying for 1 week trial, I seriously doubt it has FDA approval. She also may not get any benefits from the drug (assuming there are any) as these trials usually have control groups that use placebos and not the actual drug and the participants are not told which group they are in.


They're not always placebo-controlled - it could be a comparative trial or the 'placebo' in this case might be the treatment the patient is currently on for whatever the ailment is or it could be related to dosing levels (eg. 1000 patients on 10mg vs 1000 patients on 25 mg to see if there's any added benefit in treatment).

But as Nikki said - if your 'friend' is currently in good health - I would be pretty wary. This only seems to make sense if the person already has a condition that would benefit from treatment that perhaps the patient can't otherwise afford on their own or if their condition is so out of control that they would be willing to 'roll the dice' for a new (potentially better) option for treatment.


MissyLuvsYa
Posted: Wednesday, April 11, 2012 1:11:55 PM

Rank: Forum Guru

Joined: 3/12/2011
Posts: 543
Location: somewhere on the coast, United States
I would not take a chance doing that. You could end up being the guinea pig that is the reason they list all of those possible side effects.
SensualSharon
Posted: Wednesday, April 11, 2012 7:56:21 PM

Rank: Advanced Wordsmith

Joined: 4/29/2010
Posts: 99
Location: Canada
They should test on prisoners. No fee to pay, and constant supply of test subjects. Let those rotters finally contribute something to society for once and not just cost taxpayers money supporting their sorry asses.
The_Skye
Posted: Thursday, April 12, 2012 10:34:58 AM

Rank: Active Ink Slinger

Joined: 4/9/2012
Posts: 21
Location: United Kingdom
Okay thanks guys :) I've been trying to persuade her not to do it but we'll see, as it's not my choice...Appreciated though :) x
Jack_42
Posted: Thursday, April 12, 2012 1:21:08 PM

Rank: Forum Guru

Joined: 8/21/2009
Posts: 986
Location: Prague, Czech Republic
SensualSharon wrote:
They should test on prisoners. No fee to pay, and constant supply of test subjects. Let those rotters finally contribute something to society for once and not just cost taxpayers money supporting their sorry asses.
Now who used to do this those funny guys with armbands on?
Guest
Posted: Friday, July 20, 2012 1:39:15 PM

Rank: Lurker

Joined: 12/1/2006
Posts: 537,935
There is a big misconception as to what clinical trials are.

There are several steps that must take place before a drug can hit the market. First, it has to be proven to be effective. That is done on animal models generally. Those trials are small, but are used to determine how much of a drug is needed and what levels are safe. By safe, it doesn't mean it doesn't cause rare problems, it just means the dose that will kill you or seriously hurt you. Doing so lets them determine if the dose needed to produce an effect is safe.

After that is done, you still have to test it on humans. Afterall, we aren't rats. So a small group of people use the drug for a period of time to determine that. Usually, it's only a few weeks. They are monitored very closely during this to make sure it's not causing any serious problems. It's actually quite rare for a drug to cause life-threatening problems after that short of a trial. This trial is done to make sure it's relatively safe in humans and that it does in fact work.

Only if the drug is proven to work and is determined by the trials to be relatively safe, can it go to market. But what is relatively safe. Suppose 1 in a million people have a severe allergic reaction to the drug and it kills them. The chances of finding that out in a clinical trial are very low. So those problems aren't generally found until after they hit the market. The difference is that you generally don't have doctors checking you regularly with physicals and lab tests to make sure everything is ok.

So in essence, no drug is 100% safe. Everything has risks. The risks are higher in clinical trials because they just don't know yet. That's why they pay you. But the chances of having something serious happen to you because of it are actually quite low. Bottom line, someone has to be the first to try something out, right? If no one was willing, we wouldn't have any medications.
adele
Posted: Friday, July 20, 2012 9:26:36 PM

Rank: Forum Guru

Joined: 4/8/2011
Posts: 20,668
Location: if I knew where I was then I would not be here...
most clinical trials also look for people with certain conditions. Unless i had the condition and could not afford treatment, or was at a point where no other treatments were having an effect, i doubt i would do it

There is no mark of self,
And no mark of others,
No mark of living beings,
And no mark of a life.


-- The Diamond Sutra
MdeSade64
Posted: Thursday, September 27, 2012 4:42:57 AM

Rank: Forum Guru

Joined: 8/12/2012
Posts: 7,883
Location: United States
One week seems like a very short period of time to conduct the testing. More time that is typically needed to determine the efficacy of the product. If it is a sleeping pill, that could be different and the reason for being in residence.
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